How Do You Know That Revolution Was Put on a Cat

Topical Parasiticide For Dogs and Cats

Caution

US Federal law restricts this drug to apply by or on the order of a licensed veterinarian.

Description

Revolution (selamectin) Topical Parasiticide is available as a colorless to xanthous, gear up to use solution in unmarried dose tubes for topical (dermal) treatment of dogs half-dozen weeks of age and older and cats eight weeks of age and older. The content of each tube is formulated to provide a minimum of 2.7 mg/lb (half-dozen mg/kg) of body weight of selamectin. The chemic composition of selamectin is (5Z,25S)-25-cyclohexyl-iv'-O-de(2,6-dideoxy-iii-O-methyl-α-Fifty-arabino-hexopyranosyl)-v-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-hydroxyiminoavermectin A1a.

INDICATIONS

Revolution is recommended for use in dogs six weeks of historic period or older and cats eight weeks of age and older for the following parasites and indications:

Dogs:

Revolution kills adult fleas and prevents flea eggs from hatching for 1 calendar month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm affliction caused by Dirofilaria immitis, and the treatment and command of ear mite (Otodectes cynotis) infestations. Revolution likewise is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Cats:

Revolution kills adult fleas and prevents flea eggs from hatching for i month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the handling and control of ear mite (Otodectes cynotis) infestations. Revolution is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

WARNINGS

Not for human employ. Keep out of the reach of children.

In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching and skin redness accept been reported in humans in rare instances. Individuals with known hypersensitivity to Revolution should employ the product with caution or consult a health intendance professional. Revolution contains isopropyl booze and the preservative butylated hydroxytoluene (BHT). Wash hands after apply and wash off any product in contact with the pare immediately with soap and water. If contact with optics occurs, so affluent eyes copiously with water. In case of ingestion by a human being, contact a physician immediately. The safety data sail (SDS) provides more detailed occupational safety information. For a copy of the SDS or to study agin reactions attributable to exposure to this product, phone call one-888-963-8471.

Flammable - Keep away from oestrus, sparks, open up flames or other sources of ignition.

Do not use in sick, debilitated or underweight animals (see Safety).

PRECAUTIONS

Prior to administration of Revolution, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Revolution is non effective against adult D. immitis and, while the number of circulating microfilariae may decrease following handling, Revolution is non effective for microfilariae clearance.

Hypersensitivity reactions take not been observed in dogs with patent heartworm infections administered three times the recommended dose of Revolution. College doses were not tested.

ADVERSE REACTIONS

Pre-approval clinical trials:

Following handling with Revolution, transient localized alopecia with or without inflammation at or nigh the site of application was observed in approximately 1% of 691 treated cats. Other signs observed rarely (≤0.5% of 1743 treated cats and dogs) included airsickness, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors.

Post-approval experience:

In addition to the aforementioned clinical signs that were reported in pre-approval clinical trials, there have been reports of pruritus, urticaria, erythema, clutter, fever, and rare reports of death. There have also been rare reports of seizures in dogs (see WARNINGS).

DOSAGE

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Administer the entire contents of a unmarried dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolution topically in accordance with the following tables. (Run into Administration for the recommended treatment intervals.)

Cats (lb)	Package color	mg per tube	Potency (mg/mL)	Administered volume (mL)
Up to v	Mauve	xv mg	60	0.25
five.1–15	Bluish	45 mg	sixty	0.75
15.1–22	Taupe	60 mg	60	1.0

For cats over 22 lbs use the appropriate combination of tubes.

Dogs (lb)	Package color	mg per tube	Dominance (mg/mL)	Administered volume (mL)
Up to v	Mauve	15 mg	60	0.25
5.1–x	Purple	30 mg	120	0.25
10.1–20	Brownish	60 mg	120	0.five
20.i–40	Ruby-red	120 mg	120	one.0
forty.1–85	Teal	240 mg	120	2.0
85.1–130	Plum	360 mg	120	iii.0

For dogs over 130 lbs use the appropriate combination of tubes.

Recommended for utilize in dogs 6 weeks of age and older and in cats viii weeks of age and older.

Administration

A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolution topically to dogs and cats prior to first utilize.

Firmly press the cap downwards to puncture the seal on the Revolution tube; a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the production, part the pilus on the back of the fauna at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or four times to empty its entire contents straight onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Cheque the tube to ensure that it is empty. Do not massage the product into the skin. Due to booze content, do not apply to broken skin. Avoid contact between the product and fingers. Exercise not apply when the haircoat is wet. Bathing or shampooing the canis familiaris 2 or more hours afterward treatment will not reduce the effectiveness of Revolution confronting fleas or heartworm. Bathing or shampooing the cat 2 hours later handling will not reduce the effectiveness of Revolution confronting fleas. Bathing or shampooing the true cat 24 hours afterward handling will not reduce the effectiveness of Revolution against heartworm. Stiff hair, clumping of pilus, hair discoloration, or a slight powdery balance may be observed at the treatment site in some animals. These furnishings are temporary and do not touch on the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse.

Flea Control in Dogs and Cats

For the prevention and command of flea infestations, Revolution should exist administered at monthly intervals throughout the flea flavour, starting one month before fleas become active. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using Revolution monthly demonstrated >ninety% control of flea infestations within 30 days of the starting time dose. Dogs and cats treated with Revolution, including those with pre-existing flea allergy dermatitis, showed comeback in clinical signs associated with fleas as a direct issue of eliminating the fleas from the animals and their environment.

If the dog or cat is already infested with fleas when the get-go dose of Revolution is administered, developed fleas on the animal are killed and no feasible fleas hatch from eggs later the first assistants. However, an environmental infestation of fleas may persist for a short fourth dimension later on beginning treatment with Revolution because of the emergence of adult fleas from pupae.

Heartworm Prevention in Dogs and Cats

For the prevention of heartworm affliction, Revolution must be administered on a monthly basis. Revolution may be administered twelvemonth-round or at least within one calendar month after the animal'south first exposure to mosquitoes and monthly thereafter until the end of the musquito season. The concluding dose must exist given within ane month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then firsthand administration of Revolution and resumption of monthly dosing will minimize the opportunity for the evolution of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Revolution must be given within a month of the concluding dose of the one-time medication.

Selamectin, the active ingredient in Revolution, is a macrocyclic lactone chemical compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one calendar month of exposure to infective (Fifty3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases beneath 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using Revolution beyond two months of commencement exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of historic period), or gaps of >2 months in the assistants of Revolution during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of Revolution may be harboring pre-patent infections at the fourth dimension Revolution was started. Testing such animals iii–4 months afterward initiation of Revolution would be necessary to confirm their negative heartworm condition.

At the discretion of the veterinarian, cats ≥vi months of age may be tested to decide the presence of existing heartworm infections before beginning treatment with Revolution. Cats already infected with adult heartworms can be given Revolution monthly to foreclose further infections.

Ear Mite Treatment in Dogs and Cats

For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolution should be administered once as a single topical dose. A 2d monthly dose may be required in some dogs. Monthly apply of Revolution volition command any subsequent ear mite infestations. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the 2nd dose. Cleansing of the infested ears is recommended to remove the debris.

Sarcoptic Mange Treatment in Dogs

For the treatment of sarcoptic mange (Due south. scabiei) in dogs, Revolution should be administered once equally a single topical dose. A 2nd monthly dose may be required in some dogs. Monthly utilise of Revolution will control any subsequent sarcoptic mange mite infestations. Because of the difficulty in finding sarcoptic mange mites on peel scrapings, effectiveness assessments also were based on resolution of clinical signs. Resolution of the pruritus associated with the mite infestations was observed in approximately fifty% of the dogs 30 days afterwards the first treatment and in approximately 90% of the dogs thirty days after the second monthly handling.

Tick Control in Dogs

For the command of tick (Dermacentor variabilis) infestations in dogs, Revolution should exist administered on a monthly basis. In heavy tick infestations, consummate efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter.

Nematode Handling in Cats

For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, Revolution should exist applied once as a single topical dose.

Safety

Revolution has been tested safe in over 100 different pure and mixed breeds of healthy dogs and over 15 different pure and mixed breeds of healthy cats, including pregnant and lactating females, convenance males and females, puppies six weeks of age and older, kittens eight weeks of age and older, and avermectin-sensitive collies. A kitten, estimated to be v–vi weeks old (0.three kg), died 8 one⁄2 hours later receiving a unmarried treatment of Revolution at the recommended dosage. The kitten displayed clinical signs which included muscle spasms, salivation and neurological signs. The kitten was a devious with an unknown history and was malnourished and underweight (see WARNINGS).

DOGS:

In prophylactic studies, Revolution was administered at 1, three, 5, and 10 times the recommended dose to half-dozen-week-old puppies, and no agin reactions were observed. The safety of Revolution administered orally likewise was tested in case of accidental oral ingestion. Oral administration of Revolution at the recommended topical dose in 5- to viii-month-old beagles did non crusade any agin reactions. In a pre-clinical report selamectin was dosed orally to ivermectin-sensitive collies. Oral administration of two.5, ten, and fifteen mg/kg in this dose escalating written report did not cause whatsoever agin reactions; nevertheless, eight hours later on receiving 5 mg/kg orally, one avermectin-sensitive collie became ataxic for several hours, but did not evidence any other agin reactions afterwards receiving subsequent doses of 10 and fifteen mg/kg orally. In a topical safety study conducted with avermectin-sensitive collies at 1, 3 and 5 times the recommended dose of Revolution, salivation was observed in all handling groups, including the vehicle control. Revolution also was administered at iii times the recommended dose to heartworm infected dogs, and no adverse effects were observed.

CATS:

In rubber studies, Revolution was applied at 1, 3, v, and 10 times the recommended dose to 6-calendar week-old kittens. No adverse reactions were observed. The prophylactic of Revolution administered orally too was tested in case of accidental oral ingestion. Oral administration of the recommended topical dose of Revolution to cats caused salivation and intermittent airsickness. Revolution also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed.

In well-controlled clinical studies, Revolution was used safely in animals receiving other oft used veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

HOW SUPPLIED

Bachelor in 8 split dose strengths for dogs and cats of different weights (see DOSAGE). Revolution for puppies and kittens is available in cartons containing 3 single dose tubes. Revolution for cats and dogs is available in cartons containing 3 or 6 single dose tubes.

Approved by FDA under Nada # 141-152

zoetis

Manufactured and Distributed by:
Zoetis Inc.
Kalamazoo, MI 49007
Production of the United Kingdom

www.revolutionpet.com

40026639

Client Information

Client Information Near
REVOLUTION® (selamectin)
Revolution (pronounced "Rev-o-lu-tion")
Generic proper name: selamectin ("sel-a-mec-tin")

This summary contains of import information near Revolution. You should read this information before you commencement using Revolution on your dog or cat and review it each time your prescription is refilled. This canvas is provided simply as a summary and does not accept the place of instructions from your veterinarian. Talk to your veterinarian if you lot practise not empathize any of this information or if you desire to know more than almost Revolution.

What is Revolution?

Revolution is a topical parasiticide that is applied to the peel of dogs six weeks of age and older and cats eight weeks of age and older to kill adult fleas and prevent flea eggs from hatching, prevent heartworm disease and protect your pet against other parasites (run into below).

Why has my veterinarian prescribed Revolution?

Revolution has been prescribed by your veterinary to treat, prevent and/or control the following parasites in your dog or cat:

Domestic dog Parasites:

Control and prevention of flea infestation (Ctenocephalides felis)
Prevention of heartworm disease (Dirofilaria immitis)
Handling and control of ear mite infestation (Otodectes cynotis)
Handling and control of sarcoptic mange (Sarcoptes scabiei)
Control of the American Domestic dog Tick (Dermacentor variabilis)

Cat Parasites:

Control and prevention of flea infestation (Ctenocephalides felis)
Prevention of heartworm illness (Dirofilaria immitis)
Handling and control of ear mite infestation (Otodectes cynotis)
Treatment and command of intestinal worms
- Roundworm (Toxocara cati)
- Hookworm (Ancylostoma tubaeforme)

What should I discuss with my veterinarian before Revolution is prescribed?

Your veterinarian is best suited to hash out and recommend advisable medications for your domestic dog or cat. It is important to talk over your pet's health history with your veterinarian so he/she tin can decide if Revolution is right for your animal.

Revolution should not exist used in sick, debilitated or underweight animals.

Dogs should exist tested for heartworm disease prior to giving Revolution. If your dog tests positive for developed heartworms, your veterinary tin can recommend appropriate treatment. Dogs infected with adult heartworms can safely exist given Revolution.

If your true cat is older than half dozen months of age, your veterinarian may decide to test him/her for heartworm disease before prescribing Revolution. Cats infected with adult heartworms can be given Revolution to prevent further infections.

What dose of Revolution practice I use on my canis familiaris or cat?

Your veterinarian volition recommend the appropriate dose for your dog or cat based on your animal'due south body weight. Yous should not administer Revolution to dogs younger than 6 weeks of age or cats younger than 8 weeks of historic period. Revolution is available in eight divide dose strengths for dogs and cats of different weights.

What should I practice if I do not requite Revolution on fourth dimension or miss a dose?

If you forget to apply a monthly dose of Revolution, immediately apply Revolution, resume monthly applications, and notify your veterinary.

What if I administrate more than than the prescribed amount of Revolution to my dog or cat?

Contact your veterinarian if you administer more than the prescribed amount of Revolution.

How should Revolution be practical?

1. Remove the Revolution tube from its protective packet.
two. Property the tube upright, firmly press the cap down until yous hear a 'click' sound, which signals that the cap has punctured the applicator seal. Remove the cap and check to be sure that the tip of the tube is open up.
3. Office the hair on the back of the animal at the base of the neck, in front of the shoulder blades, until the skin is visible.
4. Use the tip of the Revolution tube straight to the skin. Squeeze the tube firmly 3–iv times in i spot until empty. Proceed tube compressed on the final squeeze to avoid drawing liquid back into tube. Avoid contact between Revolution and your fingers.
5. While keeping tube squeezed, drag information technology away from liquid and lift up to remove.
6. Ensure tube is empty.

Exercise non massage Revolution into the skin.
Exercise not use when the haircoat is wet.
Do not apply to broken pare – Revolution contains alcohol.

Potent hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the site in some animals. These furnishings are unremarkably temporary and do not affect the safety or effectiveness of the product.

Tin can I give my pet a bathroom after applying Revolution?

Yes. Bathing or shampooing the dog ii or more hours later on treatment will not reduce the effectiveness of Revolution confronting fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of Revolution against fleas. Bathing or shampooing the cat 24 hours later treatment volition not reduce the effectiveness of Revolution against heartworm.

When tin I play with my pet following handling with Revolution?

You should avoid contact with application site when wet. You may agree or play with your pet any time after the area on which Revolution was applied is dry.

I see fleas on my canis familiaris or cat. Is Revolution working?

Revolution kills developed fleas and prevents flea eggs from hatching. You may occasionally meet a few fleas on dogs or cats treated with Revolution but more than than 98% of developed fleas are killed within 36 hours.

Immature stages of the flea called pupae may be present in your pets' environment (yard, floor, rug, bedding, etc.). These pupae are non killed by parasiticides (including Revolution) and as such may emerge as adult fleas. These adult fleas may hop onto your pet at anytime. They must exist exposed to Revolution on your canis familiaris or true cat earlier being killed. It can have from 3–5 weeks (or longer depending on environmental weather condition) for most fleas to complete their 4-stage life bicycle (egg, larvae, pupae, and adult) and reach the developed stage before beingness seen on your pet. Due to the presence of young flea stages in infested environments information technology tin can have up to 2 to 3 monthly applications for Revolution to maximally control the infestation of fleas in the environment. Once the flea population is controlled you will be less likely to see fleas.

I meet ticks on my domestic dog. Is Revolution working?

Revolution controls tick infestations simply due to the American Domestic dog Tick (Dermacentor variabilis), a tick unremarkably found on dogs. There are other mutual species of ticks that are not killed or controlled by Revolution. Your veterinarian tin can recommend appropriate products to control or kill ticks common to your surface area. For the command of the American Canis familiaris Tick, Revolution should be applied in one case a month; withal, your veterinarian may recommend a second administration applied 14 days afterward the kickoff dose if your canis familiaris has a heavy tick infestation and/or recommend additional tick control methods. It may accept up to 5 days to kill the majority of ticks on your domestic dog.

What are the possible side effects of Revolution?

Like all medicines, Revolution has some side effects. The most common is hair loss at the site of application with or without inflammation (redness, flaking) in cats. Other side furnishings reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (peel redness), ataxia (incoordination), fever and rare instances of death. There have as well been rare reports of seizures in dogs.

If you lot take additional questions about possible side effects, talk to your veterinarian.

Can Revolution be given with other medicines?

In well-controlled clinical studies, Revolution was used safely in dogs and cats receiving other veterinary products such equally vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.

Tell your veterinarian about all medicines you have given your domestic dog or cat in the past, and any medicines that you are planning to use with Revolution. This should include other medicines that you can get without a prescription. Your veterinarian may want to bank check that all of your dog'southward or cat's medicines can exist given together.

How should Revolution be stored?

Revolution is flammable – Continue away from heat, sparks, open up flames or other sources of ignition. Store beneath xxx°C (86°F). Afterwards application, empty tubes can be placed in your normal household decline for disposal.

What else should I know about Revolution?

Revolution is not for utilize in humans. Revolution should exist kept out of attain of children. In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching and skin redness take been reported in humans in rare instances. Individuals with known hypersensitivity to Revolution should use the product with circumspection or consult a wellness care professional. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash easily later on use and wash off any production in contact with the skin immediately with soap and water. In case of man ingestion contact a physician immediately.

Revised: March 2019